{"id":354,"date":"2020-06-03T08:27:24","date_gmt":"2020-06-03T08:27:24","guid":{"rendered":"http:\/\/deubotehealth.com\/hk\/?p=354"},"modified":"2020-08-03T12:48:29","modified_gmt":"2020-08-03T12:48:29","slug":"%e4%b8%81%e9%85%b8%e9%b9%bd-%e7%9a%84%e6%9c%80%e4%bd%b3%e6%94%9d%e5%8f%96%e6%96%b9%e5%bc%8f-%e8%98%8b%e6%9e%9c%e6%9e%9c%e8%86%a0%e7%94%9f%e7%89%a9%e6%b4%bb%e6%80%a7%e8%bd%89%e5%8c%96-%e4%b8%81","status":"publish","type":"post","link":"https:\/\/deubotehealth.com\/hk\/blog\/2020\/06\/03\/%e4%b8%81%e9%85%b8%e9%b9%bd-%e7%9a%84%e6%9c%80%e4%bd%b3%e6%94%9d%e5%8f%96%e6%96%b9%e5%bc%8f-%e8%98%8b%e6%9e%9c%e6%9e%9c%e8%86%a0%e7%94%9f%e7%89%a9%e6%b4%bb%e6%80%a7%e8%bd%89%e5%8c%96-%e4%b8%81\/","title":{"rendered":"\u4e01\u9178\u9e7d \u7684\u6700\u4f73\u651d\u53d6\u65b9\u5f0f-\u860b\u679c\u679c\u81a0\u751f\u7269\u6d3b\u6027\u8f49\u5316\u4e01\u9178\u9e7d"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u4e01\u9178\u9e7d \u7684\u4f5c\u7528<\/h2>\n\n\n\n<p><a href=\"http:\/\/Davie, J. R. (2003). Inhibition of histone deacetylase activity by butyrate. The Journal of nutrition, 133(7), 2485S-2493S.\">\u4e01\u9178\u9e7d Butyrate<\/a>\u8fd1\u5e74\u53d7\u5230\u79d1\u5b78\u5bb6\u95dc\u6ce8\uff0c \u4e3b\u8981\u662f\u5b83\u80fd\u6291\u5236\u8eab\u9ad4\u4e00\u7a2e\u540d\u70baHDAC\u9175\u7d20\uff0c \u800c\u6291\u5236HDAC\u9175\u7d20\u80fd\u70ba\u4eba\u9ad4\u91cd\u5553\u4e00\u4e9b\u5c0d \u6297\u9811\u75c7 \u548c \u8abf\u7bc0\u514d\u75ab\u7cf8\u7d71 \u932f\u4e82\u7684\u4e00\u7a2e\u7269\u8cea\uff0c \u540c\u6642\u53c8\u80fd\u8b93\u4eba\u9ad4\u7522\u751f\u66f4\u591aBDNF\u548cGDNF\uff0c \u5c0d\u4eba\u5011\u7684\u60c5\u7dd2\u3001\u8a18\u61b6\u529b\u3001\u795e\u7d93\u53cd\u61c9\u7b49\u6709\u8457\u5f88\u5927\u76ca\u8655\u3002 \u9999\u6e2f\u4e00\u4f4d\u5b78\u8005 \u9867\u5c0f\u57f9 \u535a\u58eb\u4e5f\u66fe\u8b1b\u89e3\u4e01\u9178\u9e7d\u7684\u597d\u8655\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u651d\u53d6 \u4e01\u9178\u9e7d \u6700\u4f73\u65b9\u6cd5<\/h2>\n\n\n\n<p>\u4e01\u9178\u9e7d\u7684\u651d\u53d6\u4e3b\u8981\u53ef\u5206\u70ba\u300e\u4eba\u5de5\u5408\u6210\u548c\u63d0\u53d6\u300f\u7684\u88dc\u5145\u5291 \u53ca\u300e\u9ad4\u5167\u81ea\u7136\u751f\u7269\u6d3b\u6027\u8f49\u5316\u300f\uff0c \u300e\u4eba\u5de5\u5408\u6210\u548c\u63d0\u53d6\u300f\u7684\u88dc\u5145\u5291 \u6700\u5927\u597d\u8655\u662f\u76f4\u63a5\u800c\u53c8\u7d14\u5ea6\u6709\u4e00\u5b9a\u4fdd\u8b49\uff0c \u4f46\u53ef\u80fd\u6703\u56e0\u7d93\u904e\u80c3\u90e8\u6d88\u5316\u7b49\u56e0\u7d20\u5f71\u97ff\u6548\u679c\uff1b \u800c  \u300e\u9ad4\u5167\u81ea\u7136\u751f\u7269\u6d3b\u6027\u8f49\u5316\u300f \u9700\u8981\u900f\u904e\u76ca\u751f\u83cc\u6d88\u5316\u4e00\u4e9b\u7279\u5b9a\u76ca\u751f\u5143\u5982 \u300e<a href=\"http:\/\/deubotehealth.com\/hk\/blog\/2019\/07\/23\/hyper-pectin-%e8%b6%85%e5%87%a1%e8%98%8b%e6%9e%9c%e6%9e%9c%e8%86%a0%e5%8e%9f%e9%a3%b2\/\">\u860b\u679c\u679c\u81a0<\/a>\u300f \u6216 \u300e\u83ca\u82e3\u7cd6\u300f \u800c\u8f49\u5316\u51fa\u4e01\u9178\u9e7d\uff0c\u4e26\u5728\u8178\u9053\u76f4\u63a5\u5438\u6536\uff0c \u5176\u597d\u8655\u5728\u65bc\u662f\u9ad4\u5167\u81ea\u7136\u751f\u7269\u8f49\u5316\uff0c \u5f97\u51fa\u7684\u4e01\u9178\u9e7d\u6bd4\u8f03\u6613\u8b93\u4eba\u9ad4\u5438\u6536\u53ca\u7a7f\u904e\u8840\u8166\u5c4f\u969c\uff0c \u4ea6\u6709\u7814\u7a76\u8b49\u660e\u7531\u860b\u679c\u679c\u81a0\u8f49\u5316\u6210\u7684\u4e01\u9178\u9e7d<a href=\"http:\/\/Waldecker, M., Kautenburger, T., Daumann, H., Veeriah, S., Will, F., Dietrich, H., ... &amp; Schrenk, D. (2008). Histone-deacetylase inhibition and butyrate formation: Fecal slurry incubations with apple pectin and apple juice extracts. Nutrition, 24(4), 366-374.\">\u4e26\u7121\u7d30\u80de\u6bd2\u6027\u53ca\u5b89\u5168<\/a>\uff0c \u4f46\u5c31\u53d7\u4eba\u9ad4\u5167\u76ca\u751f\u83cc\u6578\u91cf\u548c\u83cc\u7a2e\u662f\u5426\u5145\u8db3\uff0c \u6240\u4ee5\u60f3\u4ee5 \u300e\u9ad4\u5167\u81ea\u7136\u751f\u7269\u6d3b\u6027\u8f49\u5316\u300f \u65b9\u5f0f\u651d\u53d6\u4e01\u9178\u9e7d\uff0c \u670d\u7528\u860b\u679c\u679c\u81a0\u6216\u83ca\u82e3\u7cd6\u7684\u540c\u6642\uff0c \u88dc\u5145\u76ca\u751f\u83cc\u6548\u679c\u66f4\u4f73\u3002 \u5982\u679c\u4e0d\u4ecb\u610f\u6216\u8005\u672c\u8eab\u90fd\u6709\u88dc\u5145\u76ca\u751f\u83cc\u7684\u7fd2\u6163\u7684\u4eba\u4ed5\uff0c \u7576\u7136\u6700\u597d\u9078\u64c7 \u300e\u9ad4\u5167\u81ea\u7136\u751f\u7269\u6d3b\u6027\u8f49\u5316\u300f \u662f\u6700\u81ea\u7136\u4e0d\u904e\u7684\u4e8b\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u860b\u679c\u679c\u81a0\u5728\u4e00\u4efd\u7814\u7a76\u5831\u544a\u6307\u51fa\u80fd\u8f49\u5316\u6210\u4e01\u9178\u9e7d<\/h2>\n\n\n\n<p>\u7531 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0899900707003905#!\">MarkusWaldecker<\/a> \u7b49\u5b78\u8005\u57282008\u5e74\u7684\u4e00\u9805\u7814\u7a76\u6307\u51fa\uff0c \u4e01\u9178\u5728\u7d50\u8178\u5fae\u751f\u7269\u83cc\u7fa4\u5f62\u6210\u7684 \u77ed\u93c8\u8102\u80aa\u9178 \u4e2d\u8d77\u4e3b\u8981\u4f5c\u7528\u3002 \u5b83\u88ab\u8a8d\u70ba\u662f \u7d50\u8178\u7c98\u819c \u7684\u91cd\u8981\u71df\u990a\u7d20\uff0c \u4e26\u5df2\u986f\u793a\u51fa\u53ef\u89f8\u767c\u57f9\u990a\u7269\u4e2d\u7d50\u8178\u4f86\u6e90\u7d30\u80de\u7684\u5206\u5316\u548c\u51cb\u4ea1\u3002 \u7d44\u86cb\u767d\u812b\u4e59\u9170\u57fa\u9176 \uff08HDAC\uff09 \u7684\u6291\u88fd\u4f5c\u7528\u4f3c\u4e4e\u5728\u9019\u4e9b\u4f5c\u7528\u4e2d\u8d77\u8457\u6838\u5fc3\u4f5c\u7528\u3002 \u56e0\u6b64\uff0c \u5efa\u8b70\u5c07\u4e01\u9178\u9e7d\u7528\u4f5c\u5316\u5b78\u9810\u9632\u4ee3\u8b1d\u7522\u7269\uff0c \u53ef\u4ee5\u9810\u9632\u7d50\u76f4\u8178\u9811\u75c7\u7684\u767c\u751f\uff0c 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FS\u5728HDAC\u6291\u5236\u6fc3\u5ea6\u4e0b\u6c92\u6709\u7d30\u80de\u6bd2\u6027\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"http:\/\/deubotehealth.com\/hk\/blog\/2019\/07\/23\/hyper-pectin-%e8%b6%85%e5%87%a1%e8%98%8b%e6%9e%9c%e6%9e%9c%e8%86%a0%e5%8e%9f%e9%a3%b2\/\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"576\" src=\"http:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2020\/06\/\u4e01\u9178\u9e7d-1024x576.jpg\" alt=\"\u4e01\u9178\u9e7d\u7531\u860b\u679c\u679c\u81a0\u8f49\u5316\u66f4\u6613\u5438\u6536\" class=\"wp-image-355\" srcset=\"https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2020\/06\/\u4e01\u9178\u9e7d-1024x576.jpg 1024w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2020\/06\/\u4e01\u9178\u9e7d-300x169.jpg 300w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2020\/06\/\u4e01\u9178\u9e7d-768x432.jpg 768w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2020\/06\/\u4e01\u9178\u9e7d-1536x864.jpg 1536w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2020\/06\/\u4e01\u9178\u9e7d-830x467.jpg 830w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2020\/06\/\u4e01\u9178\u9e7d-230x129.jpg 230w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2020\/06\/\u4e01\u9178\u9e7d-350x197.jpg 350w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2020\/06\/\u4e01\u9178\u9e7d-480x270.jpg 480w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2020\/06\/\u4e01\u9178\u9e7d.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><figcaption>\u4e01\u9178\u9e7d\u900f\u904e\u9ad4\u5167 \u76ca\u751f\u83cc \u628a \u860b\u679c\u679c\u81a0 \u8f49\u5316\u6210\u4e01\u9178\u9e7d\u6703\u66f4\u6613\u88ab\u4eba\u9ad4\u5438\u6536<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"> \u651d\u53d6\u4e01\u9178\u9e7d\u5c31\u9078\u64c7 \u8d85\u51e1\u860b\u679c\u679c\u81a0\u539f\u98f2<\/h2>\n\n\n\n<p>\u4e00\u76d2\u5fb7\u4fe1\u5065\u8d85\u51e1<a href=\"http:\/\/deubotehealth.com\/hk\/blog\/2019\/07\/23\/hyper-pectin-%e8%b6%85%e5%87%a1%e8%98%8b%e6%9e%9c%e6%9e%9c%e8%86%a0%e5%8e%9f%e9%a3%b2\/\">\u860b\u679c\u679c\u81a0<\/a>\u539f\u98f220\u5305\uff0c \u5fb7\u570b\u88fd\u9020\uff0c \u6bcf\u5305\u542b2\u514b\u860b\u679c\u679c\u81a0\u53ca4\u514b\u83ca\u82e3\u7cd6\u5bcc\u96c6\u4f4e\u805a\u679c\u7cd6\uff0c \u80fd\u4fc3\u9032\u76ca\u751f\u83cc\u589e\u6b96\u3001\u6d3b\u6027\u548c\u58fd\u547d\uff0c \u66f4\u6709\u6548\u4ee5 \u300e\u9ad4\u5167\u81ea\u7136 \u751f\u7269\u6d3b\u6027 \u8f49\u5316\u300f \u651d\u53d6\u4e01\u9178\u9e7d \uff0c \u4e00\u76f4\u53d7\u5230\u95dc\u6ce8\u514d\u75ab\u5065\u5eb7\u4eba\u4ed5\u4fe1\u8cf4\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" loading=\"lazy\" width=\"720\" height=\"720\" src=\"http:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2019\/07\/HyperPectin-95x95cm.jpg\" alt=\"\u4e01\u9178\u9e7d\u4f86\u81ea\u860b\u679c\u679c\u81a0\u8f49\u5316\" class=\"wp-image-102\" srcset=\"https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2019\/07\/HyperPectin-95x95cm.jpg 720w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2019\/07\/HyperPectin-95x95cm-150x150.jpg 150w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2019\/07\/HyperPectin-95x95cm-300x300.jpg 300w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2019\/07\/HyperPectin-95x95cm-230x230.jpg 230w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2019\/07\/HyperPectin-95x95cm-350x350.jpg 350w, https:\/\/deubotehealth.com\/hk\/wp-content\/uploads\/2019\/07\/HyperPectin-95x95cm-480x480.jpg 480w\" sizes=\"(max-width: 720px) 100vw, 720px\" \/><figcaption>\u5fb7\u4fe1\u5065\u8d85\u51e1\u860b\u679c\u679c\u81a0\u900f\u904e\u76ca\u751f\u83cc\u8f49\u5316\u51fa\u5929\u7136\u4e01\u9178\u9e7d<\/figcaption><\/figure>\n\n\n\n\n\n<h4 class=\"wp-block-heading\">\u5b78\u8853\u6587\u737b\u53c3\u8003<\/h4>\n\n\n\n<p><a href=\"https:\/\/academic.oup.com\/jn\/article\/133\/7\/2485S\/4688474\"> Davie, J. R. (2003). Inhibition of histone deacetylase activity by butyrate.&nbsp;<em>The Journal of nutrition<\/em>,&nbsp;<em>133<\/em>(7), 2485S-2493S. <\/a><\/p>\n\n\n\n<p> <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0899900707003905\">Waldecker, M., Kautenburger, T., Daumann, H., Veeriah, S., Will, F., Dietrich, H., &#8230; &amp; Schrenk, D. (2008). Histone-deacetylase inhibition and butyrate formation: Fecal slurry incubations with apple pectin and apple juice extracts.&nbsp;<em>Nutrition<\/em>,&nbsp;<em>24<\/em>(4), 366-374. <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e01\u9178\u9e7d \u7684\u4f5c\u7528\u4e3b\u8981\u662f\u6291\u5236HDAC\u9175\u7d20\uff0c\u5f9e\u800c\u91cd\u5553\u5929\u751f\u7684\u6297\u9811\u75c7\u7684\u529f\u80fd\uff0c\u4e5f\u6709\u52a9\u8abf\u7bc0\u514d\u75ab\u7cfb\u7d71\u554f\u984c\uff0c\u540c\u6642\u4e5f\u80fd\u589e\u52a0BDNF\u548cGDNF\uff0c\u6709\u52a9\u60c5\u7dd2\u63a7\u5236\u548c\u8a18\u61b6\uff0c\u800c\u8981\u651d\u53d6\u4e01\u9178\u9e7d\uff0c\u4e3b\u8981\u5206\u70ba\u5169\u7a2e\u65b9\u5f0f\uff0c\u300e\u4eba\u5de5\u5408\u6210\u548c\u63d0\u53d6\u300f\u7684\u88dc\u5145\u5291 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